Lipid Nanoparticles for Drug/mRNA Delivery

This course is not currently scheduled but may be offered at your company site.
Please contact Fleming for more information.

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All sessions of this unique course online

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Course description

Over the past few decades, lipid-based drug delivery, in particular, has experienced significant growth. Several lipid nanoparticle medications are already delivering better clinical results. Now that lipidic drug delivery systems can be designed to be highly responsive in vivo, they have advanced beyond being simple, inert drug carriers.

Liposomes and solid lipid nanoparticles are the most versatile and sophisticated with major advantages over other nanoparticulate drug delivery system as they offer effective drug loading, increased blood circulation due to steric stabilization.  The FDA approval of several LNP products demonstrates their great applicability in several areas such as cardiovascular disease, neurodegenerative disease, diabetes, cancer and inflammation.

On the other hand self-nanoemulsifying drug delivery systems (SNEDDS) have become progressively popular due to their capacity to enhance solubility and permeability of drug substances for oral delivery applications. Their clinical and commercial applicability has led to the development of several marketed products.

After the successful development of lipid nanoparticles (LNPs) comprising messenger RNA (mRNA) for vaccination against Covid-19, the interest in mRNA and nanoparticle systems for various therapeutic applications has surged tremendously. 

As delivery systems, currently LNPs, which are manufactured by a specific protocol with a defined mixture of four lipids are center of attention. However, there are several other nanoparticle formats which have demonstrated to be promising as delivery systems for RNA and other drugs. 

Here, concepts for nanoparticle engineering with focus on lipids and polymers are presented, for tailoring of the delivers system according to type of (RNA) cargo, application route and the intended therapeutic intervention. 

An important hurdle in developing nanomedicines is scaling up the synthesis of the particles to meet Good Manufacturing Practice standards required for moving the materials to the clinic.

An overview over strategies for manufacturing from early R&D to late clinical stage is given. A number for characterization techinques of the systems are also presented inlcuding modern formulation methodologies and scale-up approaches to overcome manufacturing limitations.

meet the training leader
Heinrich Haas
Former VP at BioNTech SE
Prof. Dimitris Fatouros
Professor
Aristotle University of Thessaloniki School of Pharmacy, Greece
Prof. Dennis Douroumis
Professor in Pharmaceutical Technology and Process Engineering
University of Greenwich, UK
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Lipid Nanoparticles for Drug mRNA Delivery online live training by Fleming_Agenda Cover
Lipid Nanoparticles for Drug mRNA Delivery online live training by Fleming_Agenda Cover
Lipid Nanoparticles for Drug mRNA Delivery online live training by Fleming_Agenda Cover
key training

Topics

Liposomes theory and classifications

Passive and active targeting strategies of lipid nanoparticles

Introduction to mRNA nanoparticles

SLNs, NLCs for drug delivery

Self-nano-emulsified drug delivery systems (SNEDDs)

Formulation, process development, scale up, GMP manufacturing of RNA nanoparticles

Analytical and control strategies, regular laboratory methods as well as methods for advanced characterization for RNA nanoparticles

Manufacturing technologies of lipid-based nanoparticles

Microfluidics for the development of lipid nanoparticles

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This course is not currently scheduled but may be offered at your company site.
Please contact Fleming for more information.

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