Course description
Advances in high-throughput screening, robotics, informatics, and miniaturization has led to an enormous number of drug substances being generated. However, an estimated 9 in 10 new drug substances exhibit solubility challenges, halting development of new medications. With the increasing complexity as well as poor solubility of new molecules in development pipelines, understanding the solubilization enhancement techniques and being able to successfully apply them in pharmaceutical manufacturing, is crucial for a company’s success.
The solubility enhancement of poorly water-soluble drugs presents a significant challenge in pharmaceutical formulation. Thanks to a scientific progress and technology development, a variety of new and promising techniques for solubilization enhancement have emerged. Salts, Cocrystals polymorphs, solvates, hydrates, and amorphous solid dispersions of drug substances are used to change the thermodynamic driving force for dissolution and increase the apparent solubility of poorly soluble drugs, without the need for covalent modification of the drug molecule. Solubility enhancement in this manner allows one to expediate the development cycle, while still being classified as a different drug entity by regulatory agencies, making them an attractive prospect across the pharmaceutical industry.
Understanding the theory, screening, processing, analysis and regulatory aspects of these solubility enhanced forms can be essential to moving your new investigative product from the lab, and into commercial processing. Therefore, it is essential that anyone involved in the development of poorly soluble drugs understand the different paths available to them.
This course provides critical insights into the novel techniques and strategies for the formulation, processing and characterization of poorly water-soluble drugs. You will gain clarifications on their successful application in pharmaceutical manufacturing as well as on characterization of enhanced drug forms and regulatory aspects.
Join us & explore how you can utilize different solubilization enhancement techniques and achieve the best possible solubility and bioavailability for your new molecules.
